Klondike was set during the early days of the Klondike Gold Rush 1897 in the town of Skagway in the Alaskan Klondike region.

The adventures of Mickey Spillane's tough-talking, brawling, skirt-chasing private detective Mike Hammer, who's always ready to use his fists on a "mug" or his charm on a "skirt" to get the case solved.